This month’s IDG news shines a light on IDG outcomes in the rodent world – namely mouse resources. And reminds you of our upcoming IDG/Open Targets meeting in Hinxton, UK focusing on 'Finding Targets For Drug Discovery.' Registration is still open.

Highlighting IDG Mouse resources

IDG consortium includes 3 DRGC (pronounced 'drugs'), all of whom are focused on Data and Resource Generation. The mouse resources stemming from IDG sponsorship are made available via the repository of MMRRC (Mutant Mouse Resource & Research Centers), as found in their major collection under ‘IDG’.  To date there are 4 resources that have been deposited:

  1. MMRRC: 050616-UCD Knock-In with cas9 and ZNF10 (zinc finger protein 10), Donor: Michael McManus (DRGC-Ion Channel) B6.Cg-Igs2,tm1(CAG-cas9*/ZNF10*)Mtm/Mmucd
  2. MMRRC: 065281-UNC CRISPR with cre recombinase and Gpr68 (G protein-coupled receptor 68), Donor: Bryan Roth C57BL/6J-Gpr68em1(cre)Blr/Mmnc
  3. MMRRC: 065282-UNC CRISPR with cre recombinase and Tas2r108 (taste receptor, type 2), Donor: Bryan Roth C57BL/6J-Tas2r108em1(Tas2r108*,cre)Blr/Mmnc   (Note: Data suggest that the mouse Tas2r108 gene is the homolog to human TAS2R4. See UniProt at 
  4. MMRRC: 065283-UNC, CRISPR with cre recombinase and Gpr85 (G protein-coupled receptor 85), Donor: Bryan Roth C57BL/6J-Gpr85em1(Gpr85*,cre)Blr/Mmnc
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IDG's European Invasion

Reminder: Take the opportunity to join us for our joint Symposium with Open Targets on ‘Finding Targets For Drug Discovery’ happening on November 15th, 2019 at the Wellcome Genome Campus in Hinxton, UK.

Registration for “Finding Targets For Drug Discovery’ symposia >>

Funding Opportunities

Here are a few funding opportunities from NIH that involved some crowdsourcing or computational algorithms of potential interest to the IDG community.

Links to RFAs on NIH sites:

Find us online

DRGC: U24 DK116195, U24 DK116204, U24 DK116214
KMC: U24 CA224370, U24 CA224260;  RDOC: U24 TR002278
CEIT: U01 CA239106, U01 CA239108, U01 CA239069
More IDG details on our IDG site or via NIH Common Fund site.
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IDG Newsletter Vol. 3, 2019-09-01

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Illuminating the Druggable Genome · 1 University of New Mexico · Albuquerque, NM 87131-0001 · USA

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