View this email in your browser
This month in CAR-T research

Welcome to the CAR-T Grease Monkeys newsletter #3: more trial data; awareness of new and long-term side-effects grows; cool new CARs from the lab; and societies from the US and Europe weigh in. Also, Donald Trump backs CAR treatment.

Happy reading, 

News from the race track

1. Phase I: Anti-CD19 CAR treatment immediately following autologous transplantation is safe:
CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma. 
Blood. 2019 Aug 15.

2. Phase II: mixing anti-BCMA and anti-CD19 CARs 1:1 in 21 myeloma patients.

A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed or refractory multiple myeloma: a single-arm, phase 2 trial.
Lancet Haematol. 2019 Aug 1.

3. Case report: PD-1 checkpoint therapy following anti-CD19 CAR treatment activates CAR-T and delays disease progression 64 days:
Rapid tumor regression from PD-1 inhibition after anti-CD19 chimeric antigen receptor T-cell therapy in refractory diffuse large B-cell lymphoma.
Bone Marrow Transplant. 2019 Aug 30.

4. Phase I: dose-escalation of anti-CD19 CAR in 10 patients safe but indicate CAR inhibition by TAMs:
Clinical Efficacy and Tumor Microenvironment Influence in a Dose-Escalation Study of Anti-CD19 Chimeric Antigen Receptor T Cells in Refractory B-Cell Non-Hodgkin's Lymphoma.
Clin Cancer Res. 2019 Aug 23.

5. Retrospecitive analysis: Study of 86 patients show long-term side-effects of CAR treatment to include hypogammaglobulinemia, infections, cytopenias and GvHD:
Late events after treatment with CD19-Targeted Chimeric Antigen Receptor Modified T-cells.
Biol Blood Marrow Transplant. 2019 Aug 13.

6. Case report: haemophagocytic lymphohistiocytosis as a differential diagnosis to CRS:
Haemophagocytic lymphohistiocytosis has variable time to onset following CD19 chimeric antigen receptor T cell therapy.
Br J Haematol. 2019 Aug 13.

7. Retrospective analysis: analysis of side-effects following allogenic or autologous CAR treatment:
A retrospective comparison of allogenic and autologous chimeric antigen receptor T cell therapy targeting CD19 in patients with relapsed/refractory acute lymphoblastic leukemia.
Bone Marrow Transplant. 2019 Aug.

8. Retrospecific analysis: gastrointestinal side-effects following anti-CD19 treatment occur in 15% of patients:
Gastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy.
Am J Clin Oncol. 2019 Aug 30.

News from the garage

9. Dual anti-CD79B/CD19 CARs works well in mice:
Chimeric antigen receptor T cells targeting CD79b show efficacy in lymphoma with or without co-targeting CD19.
Clin Cancer Res. 2019 Aug 22.

10. CARnage! Using a CAR to eliminate another CAR to avoid toxicities:
Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells.
Cancer Immunol Immunother. 2019 Aug 14.

11. Anti-B7-H3 CARs eradicate GBM in mice up to 120 days post-treatment
B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.
EBioMedicine. 2019 Aug 26.

12. Protocol for mRNA transduction in large-scale production: 
Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance. 
Cancers (Basel). 2019 Aug 16.

13. Anti-BCMA CARs are surprisingly enhanced by thalidomide-derivative lenalidomide in mice:
Anti-B-cell maturation antigen chimeric antigen receptor T cell function against multiple myeloma is enhanced in the presence of lenalidomide.
Mol Cancer Ther. 2019 Aug 8.

14. PD-1 knockdown in CAR T cells enhances T cell function short term but inhibits proliferation long-term:
PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity.
J Immunother Cancer. 2019 Aug 7.

15. The tyrosine kinase inhibitor midostaurin used in AML inhibits anti-CD33 CARs in vitro:
Midostaurin abrogates CD33-directed UniCAR and CD33-CD3 bispecific antibody therapy in acute myeloid leukaemia.
Br J Haematol. 2019 Sep.

Overheard at the shop

16. The Americans weigh in: when and how to treat non-Hodgkin lymphoma patients with CARs
Utilization of Chimeric Antigen Receptor (CAR) T Cell Therapy in Clinical Practice for Relapsed/Refractory Aggressive B cell non-Hodgkin Lymphoma: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.
Biol Blood Marrow Transplant. 2019 Aug 22.

17. The Europeans weigh in: should multiple myeloma patients be treated with CARs?
CAR-T cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network.
Haematologica. 2019 Aug 22.

18. How to treat hypogammaglobulinemia in CAR-treated patients:
CAR-T - and a side order of IgG, to go? - Immunoglobulin replacement in patients receiving CAR-T cell therapy.
Blood Rev. 2019 Aug 7.

19. Review of freezing methods for CAR T cells:
Preservation of cell-based immunotherapies for clinical trials.
Cytotherapy. 2019 Aug 12.

CARs in the news

A. Trump approves CAR T treatment under Medicare.
B. International Society for Cell and Gene Therapy warns against third party cryopreserving of T cells.
C. UpToDate publishes topic on CRS.
Our mailing address is:
Departement of clinical
OUH, J.B. Winsløws vej 4
Odense 5000

Add us to your address book

Want to change how you receive these emails?
You can update your preferences or unsubscribe from this list.

This email was sent to <<Email Address>>
why did I get this?    unsubscribe from this list    update subscription preferences
Departement of clinical · OUH, J.B. Winsløws vej 4 · Odense 5000 · Denmark

Email Marketing Powered by Mailchimp