In the Literature, cont.
RGS2 Expression Predicts Amyloid-β Sensitivity, MCI and Alzheimer’s Disease: Genome-Wide Transcriptomic Profiling and Bioinformatics Data Mining
Adva Hadar et al.
Brain deposits of amyloid-β plaques have been considered a pathological hallmark of Alzheimer’s disease (AD), but have also been found in healthy brains. Through genome-wide transcriptomic profiling, this study identified varied expression of the RGS2 gene between healthy individuals and AD patients. It is thought that RGS2 could affect whether Aβ accumulation results in the development of AD. RGS2 is a novel AD biomarker.
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The Unique Evolutionary Signature of Genes Associated with Autism Spectrum Disorder
Erez Tsur et al.
Autism spectrum disorder (ASD) genes are, on average, longer and less variable than non-ASD genes especially in the case of deleterious genetic variations, an indication of negative selection. ASD genes have evolved under complex and unique evolutionary forces, and the signature of such forces could be used to identify new candidate ASD genes.
An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility
Ariel Martinez et al.
The authors look at noncoding elements within the gene ADGRL3, which is thought to be linked to ADHD. They find the first functional evidence of noncoding variants with potential implications for the pathology of ADHD.
Association of a Genetic Risk Score with Body Mass Index Across Different Birth Cohorts
Stefan Walter et al.
Do genetic predispositions to higher body mass index (BMI) have different impacts for people in obesogenic environments? This study finds that the magnitude of association between BMI and genetic risk score for BMI was larger between people born more recently, suggesting that associations between genetic variants for higher BMIs may be modified by obesogenic environments.
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Cytoplasmic FMR1-Interacting Protein 2 is a Major Genetic Factor Underlying Binge Eating
Stacey Kirkpatrick et al.
Binge eating is a highly heritable trait, and is often comorbid with mood and substance use disorders. This study identifies a major genetic factor underlying binge eating, which offers a behavioral paradigm for future genome wide association studies and has implications for the disorders comorbid with binge eating.
Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds
Matthew Bruni et al.
This is the first behavioral and molecular genetic characterization of two auditory traits that are associated with reading in both typically developing and dyslexic readers. It found that one of those traits is genetically correlated with reading, while the other is not.
Chromosome Conformation Elucidates Regulatory Relationships in Developing Human Brain
Hyejung Won et al.
Gene expression is regulated, in part, by three-dimensional physical interactions within chromosomes. This work provides a framework for understanding these regulatory interactions within noncoding genetic regions.
Mutational Signatures Associated With Tobacco Smoking in Human Cancer
Ludmil B. Alexandrov et al.
Smoking is associated with mutations that increase the risk of at least 17 classes of human cancer. Data from this study support the hypothesis that smoking increases cancer risk by increasing the somatic mutation load, although direct evidence for this mechanism is lacking in some smoking-related cancer types.
Researchers Grow “Frankenstein Ants” to Study Epigenetics
Jeffrey M. Perkel
A molecular biologist ventures into entomology to use genetically modified ants as laboratory models of behavioral epigenetics.