August 2016

Developing a U.S. Strategy and Roadmap for Implementing 21st Century Toxicity Testing Approaches

Warren Casey, Director of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), explains the current opportunity for stakeholders to comment on the need for a U.S. implementation plan for 21st century toxicity testing approaches in the new In the Spotlight,Implementing the Vision for Toxicity Testing in the 21st Century: An Opportunity for Action.”

Scientific advancements in human-based methods for toxicity testing are outpacing their adoption by regulatory authorities. There are many obstacles to “modernizing” the practices of the U.S institutions due to their long-term reliance on animal-based methods. The behavior is as entrenched as the regulations, guidelines, and classification systems.

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) with the support of NICEATM is the organization charged with changing this status quo by enabling progress in the validation of alternative toxicological test methods and their implementation into U.S. regulatory agency policy and practices.

ICCVAM is now proposing that “In order to realize the full potential for improving and protecting human health offered by advances in science and technology, the U.S. must develop a strategy for the safe, effective, and timely implementation of human-based predictive approaches for toxicity testing.”

Public comment is being requested by ICCVAM on “the need for a U.S. strategy and roadmap for implementing 21st century toxicity testing approaches” as well as input on several specific topics “deemed important for the success of this initiative.” The need for such a plan will be one of the main topics under discussion at ICCVAM’s Scientific Advisory Board (SACATM) meeting on September 27, 2016 at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, NC. They are encouraging all stakeholders to attend in person or via webcast (registration is required) and provide comments on this extremely important initiative.

ICCVAM 2014-2015 Biennial Progress Report Now Available

The ICCVAM 2014-2015 Biennial Progress Report is now available. The report summarizes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Previous biennial progress reports are also available on the NICEATM website.

September 29-30, Research Triangle Park, NC
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September 29-30, San Diego, CA
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Upcoming Events

52nd Congress of the European Societies of Toxicology (EUROTOX 2016)
September 4–7, Seville, Spain (Note: This meeting has been moved from Turkey to Seville, Spain.)

September 4-8, Verona, Italy

SETAC Asia/Pacific 2016
September 16-19, Singapore

Environmental Mutagenesis and Genomics Society
September 24-28, Kansas City, Missouri

Immunogenomics 2016
September 26-28, Huntsville, Alabama

Lab-on-a-Chip, Microfluidics & Microarrays World Congress 2016
September 26-28, San Diego, California

Scientific Advisory Committee on Alternative Toxicological Methods
September 27-28, Research Triangle Park, North Carolina

International Conference on Nanomedicine and Nanobiotechnology
September 28-30, Paris, France

In Silico Drug Discovery and Predictive Toxicology 2016
September 29-30, San Diego, California

American Society of Cellular and Computational Toxicology
September 29-30, Research Triangle Park, North Carolina

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