‘Nano’ Today – a “New Perspective”
The varieties and uses of engineered nanomaterials in the global marketplace are growing exponentially - along with the demands to characterize and assess the safety of these materials. But nanomaterials have raised a number of testing challenges. Experimental designs for testing nanomaterials must account for many particle-specific variables such as composition, size, shape, life cycle stage, level of purity, etc., as well as situational variables including contact with other substances in the environment, characteristics of the environment, and dose-altering interaction with test assay materials – all of which influence each material's behavior. The vast number and diversity of materials make traditional animal-based testing impractical for economic, logistical, and ethical reasons.
Our latest New Perspective, "'Nano' Today," discusses the prospects for streamlining the safety-testing of nanomaterials through the use of non-animal methods and non-test strategies. Authors Monita Sharma (PISC, Ltd.) and Erik Janus (M3 Technical and Regulatory Services) provide an excellent overview of regulatory definitions of nanomaterials, characterization issues, and the potential for combining in vitro test approaches with read-across and grouping methods to assess new materials more efficiently, more effectively, and using fewer animals. Read their article here.
Reminder: ICCVAM Public Forum May 2016
ICCVAM and NICEATM will hold a public forum on May 25 in Baltimore, Maryland to update the public on member agency activities related to the development and validation of alternative test methods and approaches. Following each presentation, there will be an opportunity for participants to ask questions of ICCVAM members. The meeting will include time for participants to make public oral statements on topics relevant to the ICCVAM mission and current ICCVAM activities.
Interested persons may attend in person or view the forum remotely by webcast. Registration and statements of public comments are requested by May 13; registration is required to view the forum by webcast. More information here.
CAAT Grants 2017 Call for Preproposals
The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report, Toxicity Testing in the 21st Century: A Vision and a Strategy, in the following areas:
- Proposals Relating to Toxicology: Maximum grant amount is $25,000 per year up to 2 years. Projects should be developed to provide mechanistic understanding of computational systems biology approaches, focused on in vitro responses to toxicants in human cells. Consideration should be given to the translation of this new method to evaluate/predict health outcomes.
Deadline for preproposals: May 2, 2016.
To submit, please use the Preproposal Form. For more information: http://altweb.jhsph.edu/news/2016/2017preproposal.html
Applicants whose proposals meet the goals of the CAAT Grants Program will be invited to submit a complete grant application package.