April 2016

‘Nano’ Today – a “New Perspective”

The varieties and uses of engineered nanomaterials in the global marketplace are growing exponentially - along with the demands to characterize and assess the safety of these materials. But nanomaterials have raised a number of testing challenges. Experimental designs for testing nanomaterials must account for many particle-specific variables such as composition, size, shape, life cycle stage, level of purity, etc., as well as situational variables including contact with other substances in the environment, characteristics of the environment, and dose-altering interaction with test assay materials – all of which influence each material's behavior. The vast number and diversity of materials make traditional animal-based testing impractical for economic, logistical, and ethical reasons.

Our latest New Perspective, "'Nano' Today," discusses the prospects for streamlining the safety-testing of nanomaterials through the use of non-animal methods and non-test strategies. Authors Monita Sharma (PISC, Ltd.) and Erik Janus (M3 Technical and Regulatory Services) provide an excellent overview of regulatory definitions of nanomaterials, characterization issues, and the potential for combining in vitro test approaches with read-across and grouping methods to assess new materials more efficiently, more effectively, and using fewer animals. Read their article here.

Reminder: ICCVAM Public Forum May 2016

ICCVAM and NICEATM will hold a public forum on May 25 in Baltimore, Maryland to update the public on member agency activities related to the development and validation of alternative test methods and approaches. Following each presentation, there will be an opportunity for participants to ask questions of ICCVAM members. The meeting will include time for participants to make public oral statements on topics relevant to the ICCVAM mission and current ICCVAM activities.

Interested persons may attend in person or view the forum remotely by webcast. Registration and statements of public comments are requested by May 13; registration is required to view the forum by webcast. More information here.

CAAT Grants 2017 Call for Preproposals

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report, Toxicity Testing in the 21st Century: A Vision and a Strategy, in the following areas:
  • Proposals Relating to Toxicology: Maximum grant amount is $25,000 per year up to 2 years. Projects should be developed to provide mechanistic understanding of computational systems biology approaches, focused on in vitro responses to toxicants in human cells. Consideration should be given to the translation of this new method to evaluate/predict health outcomes.

Deadline for preproposals: May 2, 2016. 
To submit, please use the Preproposal Form. For more information:

Applicants whose proposals meet the goals of the CAAT Grants Program will be invited to submit a complete grant application package.

May 10-11, 2016, Cambridge, UK #HCPS2016
(Sponsored Listing)

New & Updated Information on

Resource Center(look for the  tag) In The Spotlight
WikiPathways: One of the Database Resources on AltTox

New Perspectives
'Nano' Today

Journal Watch
For medical device testing, an in vitro approach for assessing skin sensitization potential

Upcoming Events
Addressing Challenges in the Assessment of Botanical Dietary Supplement Safety – NTP Workshop
April 26-27, Bethesda, Maryland (and via webcast)

NICEATM-PISC webinar series, Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements, Webinar 2: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods
April 26, 11:00 AM-12:00 PM EDT

Pathways-based approaches across the biosciences: Towards application in practice
April 28, London, UK

2016 Genetic Toxicology Association
May 5-6, Newark, Delaware, US

Cell Culture Engineering XV
May 8-13, Palm Springs, California

Applied Pharmaceutical Toxicology 2016
May 18-20, Cambridge, Massachusetts

CAAT Academy: In silico modeling and tools under REACH
May 20, Cluj Napoca, Romania

SETAC Europe 2016
May 22-26, Nantes, France

European Regulatory Toxicology Conference: The Regulatory Acceptance of Alternatives to Animal Testing
May 24, Oxford, UK

ICCVAM Public Forum
May 25, Bethesda, Maryland

NICEATM-PISC webinar series, Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements, Webinar 3: State-of-the-science and Practical Application of In Silico Methods
May 26, 11:00 AM-12:00 PM EDT

More events >

Recent Blog Posts

US-Canada Regulatory Cooperation Council Meeting: May 4-5, Washington, DC

New environmental policy reports from Science for Environment Policy

NIH funding: Cell line identification tools; Human tissue models for infectious disease

April 28 ACI Webinar: The Science on Chemical Induced Asthma

FDA funding for various new studies/technologies to evaluate generic drug equivalence

EDQM symposium, “The Challenges of Quality Requirements for Fish Vaccines,” call for posters by April 15

Vaccines for Veterinary Use: A step further on the 3Rs path

ICCVAM to Hold Public Forum May 25

NCATS and FDA Hold Workshop on Assay Development for High Throughput Screening

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